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Marine
biotechnology group
The Marine Biotechnology Group leads in the adoption of
integrative strategies for the sustainable use and protection of
marine resources, detailed most recently in the Review of Marine
Research in Tropical Australia (July 2001). Priorities in
2001-02 were improving production and culturing new targets for
global markets, tapping genetic resources for new pharmaceutical
and healthcare products, trialing marine compounds effective as
agrichemicals for crop protection, and developing bioremediation
agents for environmental protection.
The Group strives to achieve a balance between applied
research geared toward commercial applications, and basic
research centred on preserving marine biodiversity and the
environment. In this capacity, it contributed to international
forums and the national agenda to develop Commonwealth and State
policies on access to biodiversity and benefit-sharing. In
September 2001, the Group also provided habitat information and
collection inventories from southern Australian sites to the
National Oceans Office Uses Assessment for the development of
the Southeast Regional Marine Plan. The Institute’s ability to
generate industry from biodiversity was recognised in the
Queensland Biodiscovery Policy Discussion Paper (April 2002).
Developing aquaculture technologies
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Tropical aquaculture output focused on prawn domestication
and genetics, the culturing of new targets including lobsters
and sponges, and advising industry on production. The Tropical
Aquaculture Project succeeded in a consortium bid with two
divisions of CSIRO and the Queensland Department of Primary
Industries for a $5.5 million project funded by the Fisheries
Research and Development Corporation (FRDC) and Industry,
looking at Understanding and removing the barriers to Penaeus
monodon domestication. AIMS benefits by $378,000 for
infrastructure and operating costs over three years.
Drs. Cherie Motti and Dianne Tapiolas
check for antibiotic activity
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This
collaborative research program is the largest of its kind in
history and brings together industry partners and the four major
agencies conducting research in tropical aquaculture. It is
receiving major support from the Australian Prawn Farmers
Association (APFA) and leading farm enterprises.
The Institute’s contribution in developing a prawn
broodstock management policy has also gained industry backing
from the APFA and Queensland Fishing Industry Development
Council, and the provisional patent Induction of spawning in
Crustacea has progressed to a national-phase application.
The sea-ranching of sponges for fine chemicals and fibres
(e.g. collagen for bone and wound healing, cosmetics, bath
sponges) attracted community interest in 2001-02. Scale-up
research was undertaken with support from FRDC and the
Queensland and Western Australian Governments. Outcomes indicate
production technologies are sustainable and economic.
Queensland-based research was successful, moving to full
external funding with $80,000 confirmed from the Department of
Aboriginal and Torres Strait Islander Policy and the Great
Barrier Reef Research Foundation. Research on sponge aquaculture
in Western Australia funded by FRDC ($352,000 over two years)
was completed with two species identified as aquaculture
targets. The compounds from these species have been placed on
the U.S. Food and Drug Administration register for clinical
trials with the National Cancer Institute. AIMS is positioned to
capitalise on this development, but lack of a biodiversity
access agreement with Western Australia has hindered efforts to
develop a viable aquaculture industry for the supply of these
drug leads in that State.
Scientists look for useful compounds
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The search for bioactive molecules from the marine
environment continues to bear fruit.
The Institute maintains a
comprehensive and diverse collection of Australasian marine
biota curated with a growing informatics database; this provides
the framework for the discovery of active compounds with
commercial application and scientific value. In 2001-02, more
than 8,000 marine macro-organisms were tested for antibiotic
activity against E. coli, and the search is being extended to
screen for anti-infectives against Staphylococcus aureus and
Candida albicans.
Corals' gene flow investigated
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Additionally, a project with James Cook
University funded by Nufarm Limited, the world’s ninth largest
agrichemical company, advanced discoveries of a novel herbicide
to the glasshouse testing stage, thus achieving a milestone in
the transfer of Intellectual Property to industry. Nufarm
reported in 2001: "Preliminary results are very
encouraging. The most promising candidate molecules so far
identified are in synthesis development at Nufarm’s French
laboratories and indicate that these organisms could be a rich
source of novel crop protection products."
AIMS continues to host the Australian Research Network for
Algal Toxins (ARNAT) which brings together more than 100
researchers in Australia, New Zealand, Canada and the US.
Genetics research aids resource management
Genetics is used at AIMS to understand the evolution and
maintenance of marine biodiversity. In the project Genetics for
Bioresource Management and Ecology, a range of DNA traits were
studied in 2001-02 to understand reproductive connections
between populations, genetic diversity within marine
populations, and the processes leading to this diversity. The
use of biotechnology in this manner aids the design and
management of Marine Protected Areas. For example, genetic data
reveals that cross-fertilisation between coral species is
important on an evolutionary timescale, but occurs infrequently
in common corals of the genus Acropora. Hence, the effects of
this cross-fertilisation are negligible and most species are
distinct genetic entities. Population studies on commercially
fished holothurians (sea cucumbers or bęche-de-mer) highlighted
the need to consider gene flow (genetic exchange between
populations) in planning biodiversity protection. Research found
that one species with unrestricted gene flow between populations
can be managed over large scales, whereas another species with a
restricted gene flow requires protection of local populations. A
forensic method was developed for identification of specimens to
determine growth and migration rates, and this technique is
amenable to other species for future conservation planning.
Scientists at AIMS are also using molecular indicators to
quantify variations in heat stress responses of coral species
during bleaching episodes on the Great Barrier Reef. Like other
organisms, corals produce heat shock proteins for protection,
and these proteins indicate to scientists the degree of heat
stress experienced. In 2001-02, scientists discovered that
Acropora millepora coral from an inshore reef was more able to
produce these protective proteins and can withstand heat stress
more than specimens living on an offshore reef. This thermal
tolerance is also correlated with the strain of symbiotic algae
or zooxanthellae living in the coral tissue. Results suggest the
ability of corals to associate with different strains of
symbiotic algae may contribute to their susceptibility to coral
bleaching.
Nature’s defences offer new possibilities
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The search for new biochemicals is complemented by examining
adaptations of marine organisms to harmful or aggressive
environments resulting in the production of biotoxins and
venoms, antifoulants, signalling agents, and other molecular
defences. Understanding the functioning of these agents provides
a strategy for the discovery of new and useful products.
In 2001-02, the discovery of a novel response by marine
bacteria to ultraviolet radiation prompted new research aimed at
shedding insight into cellular processes of human ageing and
the design of therapeutic controls to retard degenerative
processes.
Dr Andrew Negri in Antarctica
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Marine bacteria isolated from the mucus of
shallow-water corals have a biochemical adaptation that enhances
the recycling of coenzyme Q (CoQ) in their metabolism. In human
health, CoQ is vital to energy production and antioxidant
balance. AIMS research into CoQ production by marine bacteria
won support from the Australian Academy of Science and the Japan
Society for the Promotion of Science. The Institute is now
collaborating with the University of Tokyo and the Osaka City
University Medical School to take this research to the next
level.
In a similar vein, collaboration with the University of
Canterbury and logistic support from Antarctica New Zealand
underpinned AIMS research into human impacts on Antarctic
sponges. The seabed environment of the Antarctic shelf under ice
is dominated by sponges which filter hundreds of litres of
seawater per hour, making them ideal bio-indicators of pollution
near areas of human occupation. Additionally, these animals
harbour bacteria with potential to act as indicators of
metabolic stress. AIMS researchers examined the effects of
pollution on the sponges’ biochemistry and the bacteria they
host. This collaboration succeeded in gaining second-year
funding from Antarctica New Zealand and is now attracting the
interest of environmental management agencies. It provides a
novel opportunity to examine tropical-polar extremes in
comparative physiology, environmental biochemistry and the
functional ecology of marine sponges.
RESEARCH Output at a glance – MARINE BIOTECHNOLOGY
Start-up company ToxiTech Pty Ltd established with major
focus on biotechnological solutions for quality management of
seafood toxins and drinking water.
Discoveries of novel marine herbicides advanced to
glasshouse testing stage.
Major consortium bid succeeded in launching $5.5 million
project looking at Understanding and removing the barriers to
Penaeus monodon domestication.
Discovery of a novel response by marine bacteria to
ultraviolet radiation prompted new research aimed at shedding
light on human ageing and design of therapeutic controls to
retard degenerative processes. International collaboration
will help take this discovery to next level.
AIMS contributed to bioinformatics database for new CD-ROM
on Cleveland Bay, Townsville.
8,000 marine macro-organisms tested for antibiotic activity
against E.coli. This was the largest discovery effort in
Australasia for such biological activity. Leads are now under
investigation.
DNA traits of marine organisms examined to inform design of
Marine Protected Areas. Scientists shed insight on
reproductive connections between populations, genetic
diversity within marine communities, and the processes leading
to their evolution.
Population studies on commercially fished holothurians (sea
cucumbers) highlighted need to consider gene flow in planning
biodiversity protection.
Molecular indicators showed heat stress responses differ
among coral specimens. Scientists discovered adaptations of
algae living in coral tissue to environmental change may be
critical to coral bleaching.
Scale-up research shows viability of developing sponge
aquaculture for the extraction of fine chemicals and fibres.
Research into human impacts on Antarctic sponges gained
second-year external funding from Antarctica New Zealand and
attracted interest of environment management agencies.
Habitat information and collection inventories from Southern
Australian sites were given to National Oceans Office.
Group continued to provide major input to Commonwealth and
State Policies on access to biodiversity and benefit-sharing.
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